Genome Architecture Leads a Bifurcation in Cell Identity

Sijia Liu1,2,∗, Haiming Chen1,∗, Scott Ronquist1,∗, Laura Seaman1, Nicholas Ceglia3, Walter Meixner1, Lindsey A. Muir4, Pin-Yu Chen5, Gerald Higgins1, Pierre Baldi3,6, Steve Smale7,8, Alfred Hero2, Indika Rajapakse1,9,∗∗ Dept. of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Dept. of Electrical Engineering & Computer Science, University of Michigan, Ann Arbor, MI 48109, USA Dept. of Computer Science, University of California-Irvine, Irvine, CA 92697, USA Dept. of Pediatrics & Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA AI Foundations, IBM T. J. Watson Research Center, Yorktown Heights, NY 10598, USA Dept. of Biological Chemistry, University of California-Irvine, Irvine, CA 92697, USA Dept. of Mathematics, City University of Hong Kong, 999077 Hong Kong, China Dept. of Mathematics, University of California, Berkeley, CA 94720, USA Dept. of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA Contributed equally to this work Lead Contact, Correspondence: [email protected]